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VIAGRA [Sildenafil citrate] An Overview
VIAGRA [Sildenafil citrate] is the only approved and effective oral agent for the treatment of erectile dysfunction. Before that a few lines on erectile dysfunction. Erectile dysfunction [Impotence] is a condition in which erection the penis cannot be achieved during sexual intercourse/masturbation. There are many causes for erectile dysfunction. The most common cause of being increasing age. Other conditions can be: - Diabetes Mellitus - Hypertension - Heart Disease - Atherosclerosis - Lower spinal cord injury - Cancer prostate - Psychogenic - Stress Erection is achieved when there is increased blood flow to penis and hence the main organic cause is disturbance of blood flow to and from the penis. Coming back to VIAGRA [Sildenafil citrate], Viagra is a selective and potent inhibitor of cyclic guanosine monophosphate [cGMP] specific phosphodiesterase type 5 inhibitor [PDE5] which is the predominant phosphodiesterase isoform found in the penis. It is administered in doses of 25, 50 and 100 mg, and enhances erection after sexual stimulation. The onset of action is around 60-90 mins. Sildenafil (compound UK-92,480) was synthesized by a group of chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension and angina pectoris. The first clinical trials were conducted in Morriston Hospital in Swansea. Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections. VIAGRA [Sildenafil citrate] was approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction Reduced initial doses should be considered for patients, who are elderly, have renal insufficiency, or are taking medications that inhibit the CYP3A4 metabolic pathway in the liver [e.g., erythromycin, cimetidine, ketoconazole] as they may increase the serum concentration of sildenafil. The drug does not affect ejaculation, orgasm or sexual drive. When sexual stimulation causes local release of NO, inhibition of PDE5 by VIAGRA [Sildenafil citrate] causes increased levels of cGMP in the corpus cavernosum of the penis resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Side Effects: ?? Headaches ?? Facial flushing ?? ringing in ears, or sudden hearing loss ?? Dyspepsia ?? Nasal congestion. ?? Abnormal vision [blue halo effect] ?? Diarrhea ?? Dizziness ?? Rashes Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss:- Special precautions: In patients with ?? Bleeding disorders such as hemophilia ?? Liver disorder ?? Kidney disorder ?? Active peptic ulcerations and ?? Anatomical deformation of the penis, such as peyronie's disease. ?? Retinitis pigmentosa Contraindications: VIAGRA [Sildenafil citrate], is contraindicated in men receiving nitrate therapy for cardiovascular disease, including agents delivered by oral, sublingual, trans-nasal or topical routes. These agents can potentates its hypotensive effect and may result in profound shock. Viagra should be avoided in patients with congestive heart failure and cardiomyopathy because of the risk of vascular collapse.
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Learn More about
Natural Male Enhancements
A simple herbs impotence cure can boost circulation levels by up to 20%! To most men, this is the difference between being impotent and being erect. And the best part of this effective treatment is that it is completely natural and you don't have to deal with the harsh side effects from E.D. medications.
Fact! Most erectile dysfunction problems are caused by circulation problems. ... 
Erectile dysfunction means you can't get an erection hard enough for normal sexual activity. Incredibly, in the USA alone, about 15 million men suffer from erectile dysfunction and 10 million more have intermittent problems with their erections. At the age of forty, one man in twenty has erectile dysfunction; by sixty five, the problem affects one man in four. These are truly dreadful statistics,...
Are you confused because there are hundreds of erectile dysfunction herbal treatments out there? If you are serious on buying such products, all you need to know is what people are recommending. This way, you can determine which natural cures for erectile dysfunction that works and which does not. This will also separate real erectile dysfunction solutions from products that will only empty your...
In a life span of people suffering from lots of problems, so obviously they will think about those problems. And then the possible out come of those problems is stress and depression or they may addict to alcohol or any other harmful drugs. Some people making smoking habitual to get relief, interim they can feel relax for sometime but that will affect to health. Young people may feel anxiety for...
Meltabs are the soft tabs prepared by grinding up the original branded Pfizer's Viagra that is used in the treatment of the erectile dysfunction. The main constituent of the Meltabs is the Sildenafil citrate that works as the inhibitor of enzyme phosphodiesterase 5 (PDE-5) that suppresses the blood supply to the penis during the sexual stimulation. The original Meltabs were very expensive so...
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